Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation
نویسندگان
چکیده
منابع مشابه
Molecular analysis of X chromosome dosage compensation in Caenorhabditis elegans.
We used a convenient quantitative dot blot assay to measure transcript levels for two X chromosome-linked genes, myo-2 and act-4, in the nematode Caenorhabditis elegans. We show that there is dosage compensation of transcript levels for these two genes between XX hermaphrodites and X0 males and that a mutation in the dpy-21 gene, postulated from genetic analysis to be involved in control of X c...
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Studies of Caenorhabditis elegans vulval development provide a paradigm for pattern formation during animal development. The fates of the six vulval precursor cells are specified by the combined action of an inductive signal that activates the EGF receptor mitogen-activated PK signaling pathway (specifying a primary fate) and a lateral signal mediated by LIN-12/Notch (specifying a secondary fat...
متن کاملCondensin-mediated chromosome organization and gene regulation
In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the sexes. Dosage compensation initiates as cells transition from pluripotency to differentiation. In Caenorhabditis elegans, dosage compensation i...
متن کاملCondensin-Driven Remodeling of X-Chromosome Topology during Dosage Compensation
Sample Name Wild-Type replicate 1 Wild-Type replicate 2 DC Mutant replicate 1 DC Mutant replicate 2 Total Reads 266,503,508 215,734,234 151,418,128 191,241,617 Side 1 Aligned 220,076,203 174,029,683 128,872,247 160,622,937 Side 2 Aligned 199,932,153 152,253,096 121,293,537 149,367,839 Both Sides Aligned 186,500,411 147,325,957 114,228,910 140,682,829 Same Fragment 86,672,650 60,980,725 39,616,4...
متن کاملThe Caenorhabditis elegans Gene sdc - 2 Controls Sex Determination and Dosage Compensation in X X Animals Chad Nusbaum and Barbara
We have identified a new X-linked gene, sdc-2, that controls the hermaphrodite (XX) modes of both sex determination and X chromosome dosage compensation in Caenorhabditis elegans. Mutations in sdc-2 cause phenotypes that appear to result from a shift of both the sex determination and dosage compensation processes in XX animals to the X 0 modes of expression. Twenty-eight independent sdc2 mutati...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2018
ISSN: 0168-9525
DOI: 10.1016/j.tig.2017.09.010